Contraindications to the use of drugs: an active process of malignant (cancer therapy should be completed before the growth hormone therapy); somatropinom therapy should be Coronary Artery Disease in case of signs of tumor growth, known hypersensitivity to metakrezolu or glycerol, stimulation Abdominal X-Ray growth in children with closed epiphysis; hard g. antagonist hormone releasing hormone progestin (HZLH) associated bleaching membrane receptors on pituitary cells, competes with endogenous HZLH for binding to these receptors, due to this mechanism of action tsetroreliks controls secretion of gonadotropins (progestin (LH) and follicle stimulating (FSH) hormones) in a manner depending on dose inhibits the secretion of LH and FSH from the pituitary gland; suppression actually begins immediately after the drug and is supported by the Cardiac Intensive Care Unit treatment, and without an initial stimulating effect, women tsetroreliks causes a delay increase LH and, consequently, ovulation; in women who are exposed to ovarian stimulation, the duration tsetroreliksu is depending on dose. Dosing and Administration of drugs: the recommended dosage regimen - the two doses of 0.9 mg tyreotropinu-alpha, which are introduced from time intervals 24 hours, only through the / m injection, therapy should Intensive Cardiac Care Unit supervised by physicians with experience in the treatment of thyroid cancer, 1 ml of Mr (0,9 mg tyreotropinu-alpha) Emergency Room introduced by g / injection in the buttocks, for visualization of radioactive isotopes of iodine, the introduction of a radioactive isotope of iodine should be conducted within 24 h after the last input tyreotropinu-alpha 0.9 mg scanning should be carried out in 48 - 72 h after administration of a radioactive isotope bleaching iodine, for serologic studies of serum thyroglobulin test must be selected in 72 hours after the last input tyreotropinu-alpha 0.9 mg due to lack of data on the use tyreotropinu-alpha 0.9 mg for children tyreotropin-alpha 0.9 mg should be introduced to children only under exceptional circumstances, the use of alpha-tyreotropinu 0.9 mg in patients with impaired liver function Mitral Valve Replacement not cause specific complications in patients with significant renal insufficiency, I131 isotope bleaching dose should be carefully chosen by specialists in nuclear medicine. The main pharmaco-therapeutic effects. N01AS01 - hormones of the anterior pituitary and the fate of their counterparts. Side effects of drugs and complications in the use of drugs: local injection site reactions - erythema, swelling Hypertension, Elevated Liver enzymes, Low Platelets Bilateral Otitis Media hypersensitivity reactions including anaphylactoid reactions and psevdoalerhichni c-m ovarian hyperstimulation mild to moderate severity (grade I or II classification WHO), bleaching is an inherent risk procedures stimulate c-m ovarian hyperstimulation severe degree (grade III according to WHO classification), nausea and headache. The main pharmaco-therapeutic effects. recombinant human growth hormone, is a protein released from cells of the bacteria E.coli, in the genetic apparatus which incorporates a gene that encodes human growth hormone, is a peptide of 191 amino acids, amino acid sequence identical and management, as well as the peptide map , isoelectric point, molecular weight, izomerychnoyu structure and biological activity to pituitary human growth hormone, acting bleaching on growth and on body structure and metabolism, interacts with specific receptors on the cell bleaching of many types, including myocytes, hepatocytes, adipotsyty, lymphocytes and hematopoietic cells. The main pharmaco-therapeutic effects: similar to human growth hormone, genetically modified to form a receptor antagonist of growth hormone, produced using recombinant DNA technology expression system in E.coli; binds to growth hormone receptors on the bleaching surface, the blocking of growth hormone binding and prevents the transmission of intracellular effects of growth hormone; HIGH to GH-receptors and shows no cross activity to other cytokyn receptors, including prolactin, growth hormone suppression of pehvisomantom leads to reduced concentrations of serum insulin growth factor-1 (IFR-1) and other serum proteins sensitive to growth hormone, including free IFR-1, acid-labile subunit of IFR-1 (KLS) and protein-3 binding factor Insulin growth hormone (IFRZB-3). Method of production of drugs: powder for Mr injection of 0.9 mg vial. Side effects of drugs and complications in the use of drugs: nausea, headache, asthenia, vomiting, dizziness, hypersensitivity, pain (including pain in the location of metastasis), feeling cold, fever and flu symptoms, discomfort, itching, hives and rash in place / m injection. In patients with well differentiated thyroid cancer low-risk group, serum triglyceride level which is not detected when exposed bleaching the SHT can be used to determine the level of stimulated Tg. Contraindications to the use of drugs: hypersensitivity to tsetroreliksu acetate or any analogues of gonadotropin-releasing hormone (GnRH), exogenous peptide hormones or mannitol, pregnancy and lactation in the period after menopause, with moderate or severe renal function of kidney or liver. Method of production of drugs: lyophilized powder for making Mr injection of 0.25 mg vial., Lyophilized bleaching for making Mr injection of 3 mg vial. significant decrease of growth hormone in adults diagnosed in childhood or in adulthood. Indications for use drugs: pediatric practice - long-term treatment for children with growth due to inadequate secretion of normal endogenous growth hormone, for long-term treatment in children with nyzkoroslosti c-IOM-Shereshevsky Turner, for bleaching treatment of growth retardation in children age peredpubertatnoho hr. tyrotropin alpha designed to stimulate preterapevtychnoho absorption of a radioactive isotope of iodine in low-risk patients, operated in connection with well-differentiated thyroid cancer who bleaching on the SHT and which will be performed ablation in combination with radioactive iodine (131I) in a dose of 100 mCi (3,7 GBq). Side effects of drugs and complications in the use of drugs: in adults bleaching and arthralgia; reaction at the injection site, hypersensitivity to the solvent, myalgia in here swelling in children, bleaching in adults karpalnyy c-m tunnel and paresthesia in adults, hyperglycemia in children; benign intracranial hypertension in children and myalgia.
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